Users who prefer low-irritation, easy-to-use patches
If you have adjusted frequency, paused other actives, repaired the barrier, and switched formulas, and your skin still reacts, copper peptides may simply not be your ingredient
Moreover, androgen synthesis is upregulated by IGF2 that increases the expression of steroidogenic enzymes including steroid acute regulatory protein, cytochrome p450 family member 17A1, aldo-keto reductase family member 1C3, and hydroxysteroid dehydrogenase 17B3 [111, 112]
195,196,197 At the cellular level, this translates into a massive increase in cytoplasmic Na + concentration, membrane depolarisation and opening of voltage-gated Ca 2+ channels, which in turn promotes massive release of glutamate that results in even large depolarisation enlarging Na + and Ca 2+ influx thus completing the vicious circle of excitotoxic damage, as Ca 2+ overload triggers necrotic cell death